A reverse genetics approach to study feline infectious peritonitis |
| |
| Authors: | Tekes Gergely Spies Danica Bank-Wolf Barbara Thiel Volker Thiel Heinz-Jürgen |
| |
| Institution: | aInstitut für Virologie, Justus-Liebig-Universität Giessen, Giessen, Germany;bInstitute of Immunobiology, Kantonal Hospital St. Gallen, St. Gallen, Switzerland;cVetsuisse Faculty, University of Zürich, Zürich, Switzerland |
| |
| Abstract: | Feline infectious peritonitis (FIP) is a lethal immunopathological disease caused by feline coronaviruses (FCoVs). Here, we describe a reverse genetics approach to study FIP by assessing the pathogenicity of recombinant type I and type II and chimeric type I/type II FCoVs. All recombinant FCoVs established productive infection in cats, and recombinant type II FCoV (strain 79-1146) induced FIP. Virus sequence analyses from FIP-diseased cats revealed that the 3c gene stop codon of strain 79-1146 has changed to restore a full-length open reading frame (ORF). |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
