Departamento de Quimica Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón II, Ciudad Universitaria, 1428, Buenos Aires, Argentina
Abstract:
Two heparan sulphates, of different N- and O-sulphate content and iduronic/ glucuronic acid ratio (HS I and HS II), were submitted to partial periodate oxidation, borohydride reduction and subsequent O-sulphation. The sulphated derivatives showed increased anticoagulant activities by APTT assay and were significantly degraded by heparinase.