|
|||||
|
|
Chemical modification of glycosaminoglycans. Sulphation of heparan sulphate derivatives obtained by periodate oxidation/borohydride reduction |
|
| Authors: | José Kovensky Alicia Fernández Cirelli |
| Institution: | Departamento de Quimica Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón II, Ciudad Universitaria, 1428, Buenos Aires, Argentina |
| Abstract: | Two heparan sulphates, of different N- and O-sulphate content and iduronic/ glucuronic acid ratio (HS I and HS II), were submitted to partial periodate oxidation, borohydride reduction and subsequent O-sulphation. The sulphated derivatives showed increased anticoagulant activities by APTT assay and were significantly degraded by heparinase. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |