Antimicrobial agents

The development of acquired, temporary resistance induced by an adaptation mechanism as a result of direct contact of the cell with an antimycotic, was demonstrated in pathogenic species of the genusCandida. Acquired resistance induced by one substance was manifested in multiresistance to other, structurally quite different, antimycotics. Cultivation of the strain on antimycotic-free medium led to relatively rapid deadaptation and the strain regained its initial sensitivity. The sensitivity of adapted and deadapted strains was studied by the dilution method (determining MIC values) and by the “direct” Warburg method (evaluating metabolic quotients).