Reduced thymocyte development in sonic hedgehog knockout embryos |
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| Authors: | Shah Divya K Hager-Theodorides Ariadne L Outram Susan V Ross Susan E Varas Alberto Crompton Tessa |
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| Institution: | Department of Biological Sciences, Imperial College London, London, United Kingdom. |
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| Abstract: | The Hedgehog family of secreted intercellular signaling molecules are regulators of patterning and organogenesis during animal development. In this study we provide genetic evidence that Sonic Hedgehog (Shh) has a role in the control of murine T cell development. Analysis of Shh(-/-) mouse embryos revealed that Shh regulates fetal thymus cellularity and thymocyte differentiation. Shh is necessary for expansion of CD4(-)CD8(-) double-negative (DN) thymocytes and for efficient transition from the earliest CD44(+)CD25(-) DN population to the subsequent CD44(+)CD25(+) DN population and from DN to CD4(+)CD8(+) double-positive cells. |
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