Ganglionic distribution of inputs and outputs of C-PR, a neuron involved in the generation of a food-induced arousal state inAplysia |
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Authors: | Thomas Teyke Yuanpei Xin Klaudiusz R. Weiss Irving Kupfermann |
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Affiliation: | (1) Institut fur Zoologie (III) Biophysik, Johannes Guttenberg U., Saarstr. 21, 55099 Mainz, Germany;(2) Center for Neurobiology and Behavior, New York State Psychiatric Institute and College of Physicians and Surgeons of Columbia University, 10032 New York, NY, USA;(3) Department of Physiology and Biophysics and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, 1 Gustav Levy Plaza, 10029 New York, NY, USA |
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Abstract: | Cerebral neuron C-PR is thought to play an important role in the appetitive phase of feeding behavior ofAplysia. Here, we describe the organization of input and output pathways of C-PR. Intracellular dye fills of C-PR revealed extensive arborization of processes within the cerebral and the pedal ganglia. Numerous varicosities of varying sizes may provide points of synaptic inputs and outputs.Blocking polysynaptic transmission in the cerebral ganglion eliminated the sensory inputs to C-PR from stimuli applied to the rhinophores or tentacles, indicating that this input is probably mediated by cerebral interneurons. Identified cerebral mechanoafferent sensory neurons polysynaptically excite C-PR. Stimulation of the eyes and rhinophores with light depresses C-PR spike activity, and this effect also appears to be mediated by cerebral interneurons.C-PR has bilateral synaptic actions on numerous pedal ganglion neurons, and also has effects on cerebral neurons, including the MCC, Bn cells, CBIs and the contralateral C-PR. Although the somata of these cerebral neurons are physically close to C-PR, experiments using high divalent cation-containing solutions and cutting of various connectives indicated that the effects of C-PR on other cerebral ganglion neurons (specifically Bn cells and the MCC) are mediated by interneurons that project back to the cerebral ganglion via the pedal and pleural connectives. The indirect pathways of C-PR to other cerebral neurons may help to ensure that consummatory motor programs are not activated until the appropriate appetitive motor programs, mediated by the pedal ganglia, have begun to be expressed. |
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Keywords: | arousal feeding command choice |
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