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Inhibition of the release of growth hormone in vitro by -melanocyte stimulating hormone |
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| Authors: | A V Schally A Arimura A J Kastin T Uehara D H Coy E J Coy J Takahara |
| Institution: | 1. Veterans Administration Hospital, New Orleans, Louisiana, USA;2. Tulane University School of Medicine, New Orleans, Louisiana, USA |
| Abstract: | A polypeptide isolated from porcine hypothalami was found to inhibit the release of growth hormone (GH) from isolated rat pituitaries. This polypeptide was identified chemically and biologically as α-MSH. Pure natural α-MSH isolated from beef posterior pituitary extracts and synthetic α-MSH also inhibit the release of GH . In addition, other substances not yet identified, present in porcine hypothalamic extracts, also share this property. |
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