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网状内皮增生病病毒感染SPF鸡对疫苗免疫反应的抑制作用
引用本文:孙淑红 崔治中 邱玉玉. 网状内皮增生病病毒感染SPF鸡对疫苗免疫反应的抑制作用[J]. Virologica Sinica, 2006, 21(1): 34-37
作者姓名:孙淑红 崔治中 邱玉玉
作者单位:山东农业大学动物科技学院 山东泰安271018
基金项目:国家自然科学基金重点项目(#30030450),“十五”国家科技攻关计划项目(#2004BA514A18C)
摘    要:我国鸡群中网状内皮增生病病毒(REV)感染已相当普遍,但对其造成的实际危害却不太清楚。本研究结果表明,1日龄SPF鸡感染REV会显著抑制对新城疫病毒(NDV)和禽流感病毒(AIV,H5和H9)疫苗的免疫反应。1周龄用相应灭活疫苗免疫后3周、4周和5周,REV感染组对不同病毒疫苗免疫后的HI效价显著低于对照组。高剂量REV感染组的抑制作用大于低剂量感染组,但统计学差异不显著。REV感染可造成中枢免疫器官萎缩,REV感染组的胸腺、法氏囊与体重比显著低于对照组。本研究证明了,REV早期感染会干扰鸡群对NDV、AIV的免疫效果,特别是会严重干扰对AIV疫苗的免疫效果。

关 键 词:禽网状内皮增生病病毒  新城疫病毒  禽流感病毒  免疫抑制
收稿时间:2005-06-13
修稿时间:2005-07-29

Immuno-Suppression of Reticuloendotheliosis Virus Infection on Antibody Responses to Different Vaccines in SPF chickens
SUN Shu-hong, CUI Zhi-zhong, QIU Yu-Yu. Immuno-Suppression of Reticuloendotheliosis Virus Infection on Antibody Responses to Different Vaccines in SPF chickens[J]. 中国病毒学(英文版), 2006, 21(1): 34-37
Authors:SUN Shu-hong   CUI Zhi-zhong   QIU Yu-Yu
Affiliation:College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Taian 271018, China
Abstract:Avian reticuloendotheliosis virus(REV)infection was reported to be very common in chicken flocks in China,but its economic impact on the poultry industry was not clear.The results in this study indicated that REV infection in 1-day-old SPF chickens could severely suppressimmune reactions to inactivated vaccines against Newcastle disease virus(NDV)and Avian influenza virus(AIV).Hemagglutination inhibition(HI)antibody titers to NDV,AIV-H9 and AIV-H5 in REV-infected birds were significantly lower than that in the control group 3,4,and 5 weeks after vaccination at the age of 7 days.REV infection of high doses caused more severely immuno-suppression than that with low doses,but the difference between high and low doses was not significant.REV infection also caused severe atrophy of central immune organs,the ratios of thymus and the Bursa to body weight in REV-infected birds were significantly lower than that in thecontrol birds.This study demonstrated that the early REV-infection interfered vaccinations to NDV and AIV.
Keywords:Reticuloendotheliosis virus  Newcastle disease virus  Avian influenza virus  Immuno-suppression
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