Localization of corticotropin-releasing factor immunoreactivity in the brain of the teleost Sparus aurata |
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Authors: | Juan Miguel Mancera Pedro Fernández-LLebrez |
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Affiliation: | (1) Departmento de Biología Animal, Facultad de Ciencias del Mar, Universidad de Cádiz, E-11510 Puerto Real, Cádiz, Spain;(2) Departamento de Biología Animal, Facultad de Ciencias, Universidad de Málaga, E-29071 Málaga, Spain |
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Abstract: | The distribution of perikarya and fibers containing corticotropin-releasing factor (CRF) was studied in the brain of the teleost Sparus aurata by immunocytochemistry using the peroxidase-antiperoxidase method. Antisera against rat CRF, arginine vasotocin, and human adrenocorticotropin (ACTH) were used. Most CRF-immunoreactive neurons were located in the nucleus lateralis tuberis, but they were absent from the nucleus preopticus, which only contained arginine vasotocin neurons. Few CRF perikarya were identified in the nucleus preopticus periventricularis and in the mesencephalic tegmentum. A conspicuous bundle of immunoreactive fibers ran along the diencephalic floor and pituitary stalk to end near the cells of the hypophysial pars intermedia. No CRF was seen near the adenohypophysial rostral pars distalis. Our results suggest that, in Sparus aurata, CRF is a releasing factor for melanotropic cells. Its role as a releasing factor for ACTH is discussed. |
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Keywords: | Corticotropin-releasing factor Immunocytochemistry Gilthead sea bream Sparus aurata (Teleostei) |
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