Directed changes in the fatty acid spectrum of nuclear lipids and the functional state of the cellular genome

The content of polyenic fatty acids in lipids of nuclear membranes and chromatin of albino rat liver cells is established to decrease considerably in the process of ageing. It is also shown that the RNA-polymerase activity lowers with the animal age. With an increase of the content of polyunsaturated fatty acids in lipids of nuclear structures of liver cells in old animals with the aid of diet and phospholipid liposomes the RNA-polymerase activity enhances up to the level of young rats aged three months and older. However, if the relative content of polyunsaturated fatty acids in lipids of old test rats decreases with the aid of the diet to the level of the control rats aged 26 months, then the activity of RNA-polymerases falls to the level of activity in control rats of the given age group and younger.