Autohistoradiographic localization of thyrotropin-releasing hormone (TRH)-binding sites in cultured rat pituitary cells |
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Authors: | Tony Antakly Fusun Zeytinoglu Georges Pelletier Fernand Labrie |
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Affiliation: | Department of Cellular Pathology, Imperial Cancer Research Fund, Lincoln''s Inn Fields, London WC2, UK |
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Abstract: | Using an autohistoradiographic technique, it has been possible to localize specific binding sites for [3H]thyrotropin-releasing hormone (TRH) in rat anterior pituitary cells in primary culture. A low percentage (3 %) of the cells were highly labelled while 10–20% of the remaining cells showed a lower level of accumulation of radioactivity. These data provide morphological evidence for the presence of TRH-binding sites in pituitary cells and suggest a large variation of their density. |
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