Quantitative evaluation of two pathways for ethanolamine phosphoglyceride biosynthesis in rat brainin vivo |
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| Authors: | P Orlando G Arienti P Massari G Porcellati S Roberti |
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| Institution: | (1) Department of Pharmacology, Università Cattolica del S.C., Rome, Italy;(2) Department of Biochemistry The Medical School, University of Perugia, Via del Giochetto, Perugia, Italy |
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| Abstract: | 3H]Ethanolamine and 32P]orthophosphate were injected intraventricularly into adult female rats. At varying time intervals after the injection (1–10 min), the animals were killed by means of a microwave apparatus, and phosphorylethanolamine and ethanolamine phosphoglycerides were extracted from the brains and counted after separation. The kinetic constants for phosphorylethanolamine incorporation into ethanolamine lipids were calculated both from3H data and from32P data. From our results, it seems that base exchange reactions for ethanolamine incorporation into ethanolamine lipids are a pathway active in brainin vivo. |
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