Taking a look on fungi in cystic fibrosis: More questions than answers |
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| Institution: | 1. Laboratório de Bioquímica Microbiana, Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Goés, Universidade Federal do Rio de Janeiro, Brazil;2. Instituto de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, Brazil;1. National Virus Reference Laboratory, University College Dublin, Belfield, Dublin 4, Ireland;2. Respiratory Department, Children’s Health Ireland, Crumlin, Dublin 12, Ireland;3. Department of Paediatrics, Royal College of Surgeons in Ireland, Ireland;4. School of Medicine, University College Dublin, Dublin 4, Ireland;1. UMR1173, Inserm, UFR des sciences de la santé, université de Versailles-Saint-Quentin-en-Yvelines, 78180 Montigny-le-Bretonneux, France;2. Hôpital Raymond-Poincaré, GHU Paris, AP–HP, Île-de-France Ouest, 104, boulevard Raymond-Poincaré, 92380 Garches, France;1. Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Sari, Iran;2. Department of Medical Mycology, Mazandaran University of Medical Sciences, Sari, Iran;3. Student Research Committee, Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Sari, Iran;4. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran;5. Lung Transplantation Research Center (LTRC), National Research Institute of Tuberculosis and Lung Diseases (NIRTLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran;6. Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran;7. Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran;8. Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA;9. Center of Expertise in Microbiology, Infection Biology and Antimicrobial Pharmacology, Tehran, Iran;10. Medical Mycology Reference Laboratory, National Center for Microbiology, Instituto de Salud Carlos III, Madrid, Spain |
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| Abstract: | Cystic fibrosis (CF) is one of the most frequent recessive inherited diseases in western countries. Advances in medical care have led to a substantial increase in the life expectancy of CF patients. Survival beyond adolescence has permitted to see fungi not only as late colonizers, but also as potential pathogens responsible of allergic reactions and chronic infections related to lung function deterioration. The role of fungi, nevertheless, has been overlooked until recently. As a result, a number of questions on their epidemiology, clinical significance, or diagnosis, among others, remain unanswered. Besides more in depth studies about the extent of the deleterious effect of fungi on the CF host, new technologies may provide the key to understand its pathogenic role, its interaction with other microbial components of the respiratory microbiota, and should pave the way to define subsets of patients at risk who would benefit from specific therapy. This review is intended to provide a quick overview on what we know about the presence of fungi in the CF airway and its repercussion in the host, and to point out some of the many knowledge gaps needed to understand and advance in the management of fungi in the airway of CF subjects. |
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| Keywords: | Cystic fibrosis Fungal-related pathology Respiratory tract-associated fungi Fibrosis quística Enfermedad relacionada con hongos Hongos asociados al tracto respiratorio |
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