TargetCompare: A web interface to compare simultaneous miRNAs targets |
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| Authors: | Fabiano Cordeiro Moreira Bruno Dustan Igor G Hamoy André M Ribeiro-dos-Santos ?ndrea Ribeiro dos Santos |
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| Institution: | 1.Laboratorio de Genética Humana e Medica, Instituto de Ciências Biológicas, Universidade Federal do Para, Belem, PA, Brasil;2.Centro Universitário do Pará - Área de Ciências Exatas e Tecnologia, , Belém, PA, Brasil;3.Universidade Federal Rural da Amazônia, Campus de Capanema, PA, Brasil;4.Nucleo de Pesquisa em Oncologia, Universidade Federal do Para, Belem, PA, Brasil |
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| Abstract: | MicroRNAs (miRNAs) are small non-coding nucleotide sequences between 17 and 25 nucleotides in length that primarily function
in the regulation of gene expression. A since miRNA has thousand of predict targets in a complex, regulatory cell signaling
network. Therefore, it is of interest to study multiple target genes simultaneously. Hence, we describe a web tool (developed using
Java programming language and MySQL database server) to analyse multiple targets of pre-selected miRNAs. We cross validated
the tool in eight most highly expressed miRNAs in the antrum region of stomach. This helped to identify 43 potential genes that are
target of at least six of the referred miRNAs. The developed tool aims to reduce the randomness and increase the chance of
selecting strong candidate target genes and miRNAs responsible for playing important roles in the studied tissue.Availabilityhttp://lghm.ufpa.br/targetcompare |
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| Keywords: | miRNA Gastric Cancer Bioinformatics Web tool Target Genes |
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