Listeria monocytogenes Dampens the DNA Damage Response |
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| Authors: | Ascel Samba-Louaka Jorge M Pereira Marie-Anne Nahori Veronique Villiers Ludovic Deriano Mélanie A Hamon Pascale Cossart |
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| Institution: | 1. Institut Pasteur, Unité des interactions Bactéries-Cellules, Paris, France.; 2. The French National Institute of Health and Medical Research (Inserm), Paris, France.; 3. The French National Institute for Agricultural Research (INRA), Paris, France.; 4. Institut Pasteur, Laboratoire développement Lymphocytaire et Oncogénèse, Paris, France.; 5. Centre National de la Recherche Scientifique (CNRS) Paris, France.; Duke University, United States of America, |
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| Abstract: | The DNA damage response (DDR) is an essential signaling pathway that detects DNA lesions, which constantly occur upon either endogenous or exogenous assaults, and maintains genetic integrity. An infection by an invading pathogen is one such assault, but how bacteria impact the cellular DDR is poorly documented. Here, we report that infection with Listeria monocytogenes induces host DNA breaks. Strikingly, the signature response to these breaks is only moderately activated. We uncover the role of the listerial toxin listeriolysin O (LLO) in blocking the signaling response to DNA breaks through degradation of the sensor Mre11. Knocking out or inactivating proteins involved in the DDR promotes bacterial replication showing the importance of this mechanism for the control of infection. Together, our data highlight that bacterial dampening of the DDR is critical for a successful listerial infection. |
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