Genetic Polymorphisms in VIR Genes among Indian Plasmodium vivax Populations |
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| Authors: | Purva Gupta Veena Pande Aparup Das Vineeta Singh |
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| Institution: | 1.National Institute of Malaria Research, Sector-8 Dwarka, New Delhi-110077, India.;2.Department of Biotechnology, Kumaun University, Nainital, Uttarakhand, 263001, India. |
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| Abstract: | The vir genes are antigenic genes and are considered to be possible vaccine targets. Since India is highly endemic to Plasmodium vivax, we sequenced 5 different vir genes and investigated DNA sequence variations in 93 single-clonal P. vivax isolates. High variability was observed in all the 5 vir genes; the vir 1/9 gene was highly diverged across Indian populations. The patterns of genetic diversity do not follow geographical locations, as geographically distant populations were found to be genetically similar. The results in general present complex genetic diversity patterns in India, requiring further in-depth population genetic and functional studies. |
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| Keywords: | Plasmodium vivax vir gene DNA sequence polymorphism India |
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