Ancient diversification of eukaryotic MCM DNA replication proteins |
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Authors: | Yuan Liu Thomas A Richards and Stephen J Aves |
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Institution: | (1) Centre for Eukaryotic Evolutionary Microbiology, School of Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter, EX4 4QD, UK;(2) School of Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter, EX4 4QD, UK |
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Abstract: | Background Yeast and animal cells require six mini-chromosome maintenance proteins (Mcm2-7) for pre-replication complex formation, DNA
replication initiation and DNA synthesis. These six individual MCM proteins form distinct heterogeneous subunits within a
hexamer which is believed to form the replicative helicase and which associates with the essential but non-homologous Mcm10
protein during DNA replication. In contrast Archaea generally only possess one MCM homologue which forms a homohexameric MCM
helicase. In some eukaryotes Mcm8 and Mcm9 paralogues also appear to be involved in DNA replication although their exact roles
are unclear. |
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