| 多基因离散性状QTL连锁分析方法 |
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| 引用本文： | 殷宗俊,张勤. 多基因离散性状QTL连锁分析方法[J]. 遗传, 2006, 28(5): 578-582 |
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| 作者姓名： | 殷宗俊 张勤 |
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| 作者单位： | 1.安徽农业大学动物科技学院，合肥 230036；2.中国农业大学动物科技学院，北京 100094 |
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| 基金项目： | 国家重点基础研究发展计划(973计划)，安徽省教育厅科技攻关项目 |
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| 摘 要： | 动物中有许多重要的离散性状，与常规的数量性状类似，其遗传基础受多基因控制并受到环境因子的修饰。由于多基因离散性状的表型特殊性，利用常规的QTL连锁分析方法很难获得理想的统计效果，相应地发展了许多基于广义线性模型框架内的非线性方法。本文就目前离散性状的QTL连锁分析方法作简要综述，并对可预期的改进方法进行了展望。
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| 关 键 词： | 离散性状 QTL 广义线性方法 连锁分析 |
| 文章编号： | 0253-9772(2006)05-0578-05 |
| 收稿时间： | 2005-05-08 |
| 修稿时间： | 2005-07-10 |
Methodology of QTL's Linkage Analysis for Discrete Traits Controlled by Polygenes |
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| YIN Zong-Jun,ZHANG Qin. Methodology of QTL's Linkage Analysis for Discrete Traits Controlled by Polygenes[J]. Hereditas, 2006, 28(5): 578-582 |
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| Authors: | YIN Zong-Jun ZHANG Qin |
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| Affiliation: | 1. College of Animal Science and Technology, AnHui Agricultural University, Hefei 230036,China； 2. College of Animal Science and Technology, China Agricultural University, Beijing 100094,China |
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| Abstract: | Many characters of biological interest and economical importance that are not inherited in a simple Mendelian fashion vary in a discrete form. These traits are called complex discrete traits. A complex discrete trait is presumably controlled by several genes, and characteristic of the trait is modified by environmental effects. Although methods of mapping QTL for continuous quantitative characters have been well developed, such methods for discrete characters are not available yet. So many non-linear methods were developed under the framework of the generalized linear model. In this paper, we reviewed the recent progress and improvement of the methods for QTL mapping in this field. |
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| Keywords: | QTL |
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