Role of host reticulon proteins in rearranging membranes for positive-strand RNA virus replication |
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Authors: | Diaz Arturo Ahlquist Paul |
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Affiliation: | Institute for Molecular Virology, University of Wisconsin-Madison, Madison, WI 53706, United States. |
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Abstract: | Positive-strand RNA [(+)RNA] viruses are responsible for numerous human, animal, and plant diseases. Because of the limiting coding capacity of (+)RNA viruses, their replication requires a complex orchestration of interactions between the viral genome, viral proteins and exploited host factors. To replicate their genomic RNAs, (+)RNA viruses induce membrane rearrangements that create membrane-linked RNA replication compartments. Along with substantial advances on the ultrastructure of the membrane-bound RNA replication compartments, recent results have shed light into the role that host factors play in rearranging these membranes. This review focuses on recent insights that have driven a new understanding of the role that the membrane-shaping host reticulon homology domain proteins (RHPs) play in facilitating the replication of various (+)RNA viruses. |
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