Reversible ADP-ribosylation as a mechanism of enzyme regulation in procaryotes |
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| Authors: | Paul W. Ludden |
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| Affiliation: | (1) Department of Biochemistry, University of Wisconsin, 53706 Madison, WI, USA |
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| Abstract: | Several cases of ADP-ribosylation of endogenous proteins in procaryotes have been discovered and investigated. The most thoroughly studied example is the reversible ADP-ribosylation of the dinitrogenase reductase from the photosynthetic bacteriumRhodospirillum rubrum and related bacteria. A dinitrogenase reductase ADP-ribosyltransferase (DRAT) and a dinitrogenase reductase ADP-ribose glycohydrolase (DRAG) fromR. rubrum have been isolated and characterized. The genes for these proteins have been isolated and sequences and show little similarity to the ADP-ribosylating toxins. Other targets for endogenous ADP-ribosylation by procaryotes include glutamine synthetase inR. rubrum andRhizobium meliloti and undefined proteins inStreptomyces griseus andPseudomonas maltophila. |
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| Keywords: | ADP-ribosylation nitrogen fixation nitrogenase dinitrogenase reductase photosynthetic bacteria nif dra glutamine synthetase signal transduction |
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