Role of peptide YY in regulation of duodenal motility during the interdigestive period in sheep |
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Authors: | Takenori Onaga Shin Kubagawa Sohtetsu Lee Hitoshi Mineo Seiyu Kato Satoru Naruse Tsuyoshi Ozaki |
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Institution: | (1) Veterinary Physiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069, Japan, Tel.: +81-11/386-1112, ext. 4336, Fax: +81-11/387-5890, JP;(2) Second Department of Internal Medicine, Nagoya University School of Medicine, Nagoya 466, Japan, JP;(3) National Institute for Physiological Sciences, Okazaki 444, Japan, JP |
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Abstract: | Temporal coordination between duodenal migrating myoelectric complexes (MMC) and pancreatic exocrine secretion, and the effects
of porcine peptide YY (PYY) on gastroduodenal motility and pancreatic exocrine secretion were examined during the interdigestive
period in conscious mature sheep. Fluid and enzyme secretions from the exocrine pancreas showed a periodic pattern corresponding
to the phases of duodenal MMC, although these secretion rates were maintained at a high level during phase II in sheep. Intravenous
continuous infusion of PYY at doses ranging from 50 to 200 pmol · kg−1 · h−1 or intravenous bolus infusion of PYY at doses ranging from 50 to 200 pmol · kg−1 showed a tendency to prolong the first cycle of the duodenal MMC and significantly shorten the second cycle. However, there
was almost no effect on ruminal contractions from the PYY administration. In the pancreatic exocrine secretion, PYY could
inhibit only bicarbonate secretion at only the highest dose of 200 pmol · kg−1. These results imply that endogenous PYY may play a physiological role in the regulation of the duodenal MMC cycles in sheep
but not in ruminal contractions. PYY seems unlikely to regulate the pancreatic exocrine secretion in normal sheep, because
a supraphysiological dose of PYY was required to inhibit the pancreatic exocrine secretion.
Accepted: 3 March 1997 |
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Keywords: | PYY Rumen Duodenum MMC Exocrine pancreas |
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