Sustained Release Tablets Containing Soluble Polymethacrylates: Comparison with Tableted Polymethacrylate IPEC Polymers |
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| Authors: | Wasfy M. Obeidat Alaa H. Abuznait Al-Sayed A. Sallam |
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| Affiliation: | 1College of Pharmacy, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates ;2Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe, Louisiana 71201 USA ;3The Specialized Pharma. Res. Co. (STD), P.O. Box 961040, Amman, 11196 Jordan ;4Jordan University of Science and Technology, P.O. Box 3030 Irbid, 22110 Jordan |
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| Abstract: | The objective of this study was to compare a novel sustained release tablet formulation that has the potential to be used for drugs of different physicochemical properties using a binary mixture of polymethacrylate polymers in their salt forms with the polymethacrylate interpolyelectrolyte complex (IPEC) tablets in terms of drug release and compactness. Also, we aimed to compare this formulation with an IPEC tablet in terms of drug release. Tablets prepared using Eudragit E-Citrate and Eudragit L-Sodium were more convenient, easier to prepare, and showed better sustained release and compactness characteristics compared to IPEC tablets of similar concentrations and preparation methods. |
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