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Sulf1 and Sulf2 Differentially Modulate Heparan Sulfate Proteoglycan Sulfation during Postnatal Cerebellum Development: Evidence for Neuroprotective and Neurite Outgrowth Promoting Functions |
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| Authors: | Ina Kalus Susanne Rohn Tania M. Puvirajesinghe Scott E. Guimond Pieter J. Eyckerman-K?lln Gerdy ten Dam Toin H. van Kuppevelt Jeremy E. Turnbull Thomas Dierks |
| Affiliation: | 1 Fakultät für Chemie, Biochemie I, Universität Bielefeld, Bielefeld, Germany, ; 2 Centre for Glycobiology, School of Biological Sciences, University of Liverpool, Liverpool, United Kingdom, ; 3 Department of Biochemistry, University of Nijmegen, Nijmegen, The Netherlands, Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegan, The Netherlands, ; Columbia University, UNITED STATES, |
| Abstract: | IntroductionSulf1 and Sulf2 are cell surface sulfatases, which remove specific 6-O-sulfate groups from heparan sulfate (HS) proteoglycans, resulting in modulation of various HS-dependent signaling pathways. Both Sulf1 and Sulf2 knockout mice show impairments in brain development and neurite outgrowth deficits in neurons.ConclusionSulfs introduce dynamic changes in HS proteoglycan sulfation patterns of the postnatal cerebellum, thereby orchestrating fundamental mechanisms underlying brain development. |
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