<Emphasis Type="Italic">atonal</Emphasis>- and <Emphasis Type="Italic">achaete-scute</Emphasis>-related genes in the annelid <Emphasis Type="Italic">Platynereis dumerilii</Emphasis>: insights into the evolution of neural basic-Helix-Loop-Helix genes |
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| Authors: | Elena Simionato Pierre Kerner Nicolas Dray Martine Le Gouar Valérie Ledent Detlev Arendt Michel Vervoort |
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| Institution: | 1.Evolution et Développement des métazoaires,Centre de Génétique Moléculaire-UPR 2167 CNRS,Gif-sur-Yvette,France;2.Belgian EMBnet Node – Laboratoire de Bioinformatique,Université Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires,Gosselies,Belgium;3.Developmental Biology Unit,European Molecular Biology Laboratory,Heidelberg,Germany;4.UFR Sciences du Vivant,Université Paris Diderot – Paris 7,Paris Cedex 13,France |
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| Abstract: | Background Functional studies in model organisms, such as vertebrates and Drosophila, have shown that basic Helix-loop-Helix (bHLH) proteins have important roles in different steps of neurogenesis, from the
acquisition of neural fate to the differentiation into specific neural cell types. However, these studies highlighted many
differences in the expression and function of orthologous bHLH proteins during neural development between vertebrates and
Drosophila. To understand how the functions of neural bHLH genes have evolved among bilaterians, we have performed a detailed study
of bHLH genes during nervous system development in the polychaete annelid, Platynereis dumerilii, an organism which is evolutionary distant from both Drosophila and vertebrates. |
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