Liposome formulation of NSC-639829 using halothane as a solvent: A technical note |
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| Authors: | Akash Jain Tapan Sanghvi Samuel H Yalkowsky |
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| Institution: | (1) College of Pharmacy, The University of Arizona, 1703 E Mabel Street, Room #441, 85721 Tucson, AZ |
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| Abstract: | Conclusion Halothane has been successfully used as a solvent for the liposome formulation of NSC-639829. Liposomes with similar morphology,
particle size, incorporation efficiency, and stability were obtained with halothane, chloroform, and ether. Halothane provides
additional ease in formulation because of its higher volatility and safety as compared with chloroform and ether. Halothane
can be regarded as a safe alternative to chloroform or ether in liposome formulation. |
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| Keywords: | halothane chloroform liposome ether |
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