The effect of bacterial antigens on lymphocyte immune receptors in mice

It has been shown that the treatment of a suspension of lymphocytes obtained from spleens in mice by LPS S. sonnei as well as by exotoxins Cl. tetani and Cl. botulinum has led to a notable reduction in the number of luminescent cells by comparison with control samples. The action of tested remedies was found to increase with their concentration. These was complete correlation between these results and the data obtained by the immunity rosette formation method. A reliable reduction was also noted in the number of lymphocytes forming rosettes with the sheep erythrocytes. It has been inferred that the bacterial products tested possessed a marked capacity for blocking the immune receptors of lymphocytes.