NMDA受体与中枢神经系统的发育

离子型谷氨酸受体分为NMDA型和非NMDA型两类,其中NMDA型受体与中枢神经系统发育关系密切。本文综述了NMDA受体的分子特性及NMDA受体五种亚单位NR1、NR2A、NR2B、NR2C和NR2D在动物出生后脑内的时空表达;NMDA受体亚单位在发育中的作用以及NMDA受体活性的胞内调节机制。

NMDA receptors and development of central nervous system

The ionotropic glutamate receptors are divided into NMDA and non NMDA receptors. The NMDA receptors play an important role in development of central nervous system. In this report we have reviewed the molecular characters of NMDA receptors and spatial temporal expression of five NR subunits in postnatal animal brain. The effect of NR subunits on development and the intracellular regulation mechanism of NMDA receptors are also reviewed.