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Genome-wide association study in Han Chinese identifies three novel loci for human height |
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| Authors: | Yongchen Hao Xuehui Liu Xiangfeng Lu Xueli Yang Laiyuan Wang Shufeng Chen Hongfan Li Jianxin Li Jie Cao Jichun Chen Ying Li Liancheng Zhao Yongyong Shi Chong Shen Weili Yan Jiang He Jianfeng Huang Dongfeng Gu |
| Institution: | 1. State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China 2. National Human Genome Center at Beijing, Beijing, China 3. Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Bio-X Institutes, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China 4. Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China 5. Division of Clinical Epidemiology, Pediatric Institute, Children’s Hospital of Fudan University, Shanghai, China 6. Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA |
| Abstract: | Human height is a complex genetic trait with high heritability but discovery efforts in Asian populations are limited. We carried out a meta-analysis of genome-wide association studies (GWAS) for height in 6,534 subjects with in silico replication of 1,881 subjects in Han Chinese. We identified three novel loci reaching the genome-wide significance threshold (P < 5 × 10?8), which mapped in or near ZNF638 (rs12612930, P = 2.02 × 10?10), MAML2 (rs11021504, P = 7.81 × 10?9), and C18orf12 (rs11082671, P = 1.87 × 10?8). We also confirmed two loci previously reported in European populations including CS (rs3816804, P = 2.63 × 10?9) and CYP19A1 (rs3751599, P = 4.80 × 10?10). In addition, we provided evidence supporting 35 SNPs identified by previous GWAS (P < 0.05). Our study provides new insights into the genetic determination of biological regulation of human height. |
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