SAR studies on a novel series of human cytomegalovirus primase inhibitors |
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| Authors: | Chen X Adrian J Cushing T Dimaio H Liang L Mayorga V Miao S Peterson M G Powers J P Spector F Stein C Wright M Xu D Ye Q Jaen J |
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| Affiliation: | Amgen Inc., 1120 Veterans Boulevard ASF2-3, South San Francisco, CA 94080, USA. xiaoqic@amgen.com |
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| Abstract: | A novel series of imidazolylpyrimidines were found to possess inhibitory activity against the human CMV UL70 primase. Extensive SAR studies on an HTS lead led to potent, orally bioavailable compounds with anti-CMV IC(50) values of 150 nM in both viral yield and viral DNA replication assays and with a much reduced cytotoxicity compared to marketed treatments ganciclovir and cidofovir. |
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