Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles |
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Authors: | Simón Diana García-García Esther Royo Felix Falcón-Pérez Juan Manuel Avila Jesús |
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Institution: | Centro de Biología Molecular Severo Ochoa, CSIC/UAM, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain. dsimon@cbm.uam.es |
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Abstract: | Increasing amounts of tau protein were expressed in non-neuronal cells. When intracellular amounts reached a threshold level, tau protein was released to the extracellular culture medium in association with membrane vesicles. Hence, we propose that tau might be secreted through membrane vesicles as a cellular mechanism to eliminate the excess of tau protein, thereby avoiding its toxicity. |
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