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Tetrahydrofluorenones with conformationally restricted side chains as selective estrogen receptor beta ligands |
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| Authors: | Wildonger Kenneth J Ratcliffe Ronald W Mosley Ralph T Hammond Milton L Birzin Elizabeth T Rohrer Susan P |
| Affiliation: | Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. ken_wildonger@merck.com |
| Abstract: | A series of 2-9a bridged tetrahydrofluorenone derivatives were prepared which exhibited significant binding affinity for ERbeta and were highly selective. |
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