Human erythrocyte P and Pk blood group antigens: identification as glycosphingolipids |
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Authors: | M Naiki D M Marcus |
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Institution: | Departments of Microbiology and Immunology, and Medicine, Albert Einstein College of Medicine, Bronx, N.Y. 10461 USA |
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Abstract: | The human erythrocyte P blood group system consists of three known antigens, P1, P and Pk. We have identified the P antigen as the glycosphingo-lipid globoside, βGalNAc(1→3)αGal(1→4)βGal(1→4)Glc-cer, and the Pk antigen as ceramide trihexoside, αGal(1→4)βGal(1→4)Glc-cer. These data suggest, in contrast to previous hypotheses, that the Pk antigen is a biosynthetic precursor of P, and that neither P nor Pk is a precursor of P1. These findings also provide an explanation for the apparent recessive inheritance of the Pk antigen, and for the nature of the biochemical abnormality in individuals of the rare Pk and p phenotypes. |
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Keywords: | Gal -Galactose Glc -Glucose GalNAc N-acetyl-D-galactosamine GlcNAc -acetyl-D-glucosamine NAN N-acetylneuraminic acid Ceramide -acylsphingosine PBS phosphate-buffered saline 0 02 M potassium phosphate pH 7 3 0 15 M NaCl |
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