Origin of renal proximal tubular injuries by Fe(III)-nta chelate |
| |
Authors: | Nishida Yuzo Ito Yuuta Satoh Takahiro |
| |
Institution: | Department of Chemistry, Faculty of Science, Yamagata University, Yamagata 990-8560, Japan. yuzo@sci.kj.yamagata-u.ac.jp |
| |
Abstract: | Interaction between apo-transferrin and several iron(III) chelates has been investigated in terms of the capillary electrophoresis method. Based on the results, it has been clarified that (i) a binuclear iron(III) unit with an oxo-bridge is necessary for the facile transfer of an iron atom from the iron(III) chelate to apo-transferrin, and (ii) the renal proximal tubular injuries by Fe(III)-nitrilotriacetate (Fe-nta) should be due to the unique binuclear structure of this complex, which gives a peroxide adduct of the binuclear Fe-nta in the presence of glutathione cycle and oxygen. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|