Linkage in mice of genes controlling an immunoglobulin kappa-chain marker and the surface alloantigen Ly-3 on T lymphocytes |
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| Authors: | J Latham Claflin Benjamin A Taylor Marianna Cherry Marge Cubberley |
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| Institution: | (1) Department of Microbiology, University of Michigan Medical School, 48109 Ann Arbor, Michigan;(2) The Jackson Laboratory, 04609 Bar Harbor, Maine |
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| Abstract: | Evidence obtained using recombinant inbred and congenic mouse strains has shown that thePC8 locus responsible for determining a marker on a singlek chain in inbred mice is linked to theLy-2,3 locus on chromosome 6. The upper limit of the map distance between these loci is approximately three centimorgans. This finding is discussed in relation to other known light-chain variants that are associated with theLy-2,3 locus.Abbreviations used in this paper are as follows L
light chains
- PC
phosphocholine
- H8
HOPC 8
- IEF
isoelectric focusing
- KLH
keyhole limpet hemocyanin
- RI
recombinant inbred |
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