MEGAKARYOCYTOPOIESIS IN MICE |
| |
| Authors: | T T Odell Jr E A Burch Jr C W Jackson T J Friday |
| |
| Institution: | Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee |
| |
| Abstract: | Megakaryocytopoiesis was investigated in young RFM/Unf mice by determining in autoradiograms of marrow smears the labeling index (percentage of cells labeled) of morphologic stages of megakaryocytes at intervals after a single injection of tritiated thymidine. The total maturation time of recognizable megakaryocytes is estimated to be 50–57 hr. The average times spent in the Type I (immature) and Type II (mature) compartments are, respectively, 15 and 42 hr, but we believe that there is a wide variation in these periods among individual megakaryocytes. The frequencies of megakaryocytes of Types I, II and III are 10, 86 and 4%, respectively. |
| |
| Keywords: | |
|
|
