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INVO: a simple, low cost effective assisted reproductive technology
Authors:Frydman  R; Ranoux  C
Institution: 1 Univ Paris-Sud, Clamart F-92140 Paris, France
2 AP-HP, Service de Gynécologie-Obstétrique et Médecine de la Reproduction, Hôpital Antoine Béclère, Clamart, F-92141 Paris, France
3 INSERM, U782, Clamart, F-92140 Paris, France
4 BioXcell Inc, 100 Cummings Center, Suite 421E, Beverly, MA 01915 USA
Abstract:5Correspondence address. E-mail: clauderanoux{at}bioxcell.com INVO procedure is a simple and effective infertility treatmentthat uses a new device, the INVOcell. INVO can be performedin a physician's office or in a satellite facility of an IVFcenter. The INVO procedure consists of fertilization of oocyte(s)and early embryo development in the INVOcell placed into thematernal vaginal cavity for incubation. The vaginal cavity replacesthe complex in vitro fertilization (IVF) laboratory. This studypresents the specially designed device, INVOcell that has receivedCE Certification. INVOcell overcomes the disadvantages of thepreviously used prototype and makes the procedure simpler andreproducible. INVO is a proven procedure that has demonstratedcomparable results to conventional IVF when comparative studieswere performed. Over 800 cycles have been published worldwidethat showed a clinical pregnancy rate of 19.6%. The INVO technologycan be performed in an office setting with minor capital equipment.INVO is a simple low-cost procedure that can be available almosteverywhere. INVO allows the treatment of a new population ofinfertile couples who could not benefit from IVF due to costand availability. The participation of the patient in the processof fertilization and early embryo development is a psychologicalbenefit that creates a high level of acceptance of INVO.
Keywords:INVOcell device  intravaginal culture  in vitro fertilization  office setting procedure  low cost
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