Statistical methodology for the analysis of dye-switch microarray experiments |
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Authors: | Tristan Mary-Huard Julie Aubert Nadera Mansouri-Attia Olivier Sandra Jean-Jacques Daudin |
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Affiliation: | (1) UMR AgroParisTechINRA 518, 16, rue Claude Bernard 75231, Paris, CEDEX 05, France;(2) UMR INRA/ENVA/CNRS 1198, Jouy en Josas, France |
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Abstract: | Background In individually dye-balanced microarray designs, each biological sample is hybridized on two different slides, once with Cy3 and once with Cy5. While this strategy ensures an automatic correction of the gene-specific labelling bias, it also induces dependencies between log-ratio measurements that must be taken into account in the statistical analysis. |
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