Irregular chiasm-C-roughest, a member of the immunoglobulin superfamily, affects sense organ spacing on the Drosophila antenna by influencing the positioning of founder cells on the disc ectoderm |
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| Authors: | G Venugopala Reddy Christian Reiter Shubha Shanbhag Karl-Friedrich Fischbach V Rodrigues |
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| Institution: | Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400005, India E-mail: veronica@tifr.res.in Tel.: +91-22-2152971 ext 2529 Fax: +91-22-2152110, IN
Institut für Biologie III, Universit?t Freiburg, Sch?nzlestrasse 1, D-79104 Freiburg, Germany, DE
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| Abstract: | We describe a role for Irregular chiasmC-roughest (IrreC-rst), an immunoglobulin (Ig) superfamily member, in patterning sense
organs on the Drosophila antenna. IrreC-rst protein is initially expressed homogeneously on apical profiles of ectodermal cells in regions of the
antennal disc. During specification of founder cells (FCs), the intracellular protein distribution changes and becomes concentrated
in regions where specific intercellular contacts presumably occur. Loss of function mutations as well as misexpression of
irreC-rst results in an altered arrangement of FCs within the disc compared to wildtype. Sense organ development occurs normally, although
spacing is affected. Unlike its role in interommatidial spacing, irreC-rst does not affect apoptosis during antennal development. We propose that IrreC-rst affects the spatial relationship between
sensory and ectodermal cells during FC delamination.
Received: 19 January 1999 / Accepted: 10 May 1999 |
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| Keywords: | Irregular chiasm-C-roughest Immunoglobulin domain superfamily Adhesion molecules Olfactory sense organs Antennal disc |
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