Tuberculosis-like lesions arising from the use of Freund's complete adjuvant in an owl monkey (Aotus sp.) |
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Authors: | Málaga Carlos A Weller Richard E Roger Broderson J Gozalo Alfonso S |
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Affiliation: | University of Puerto Rico, San Juan, Puerto Rico. |
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Abstract: | An apparently normal, non-tuberculin-reacting, splenectomized owl monkey presented tuberculosis-like lesions of the lung at necropsy. Histological and bacteriological examination failed to demonstrate the presence of acid-fast organisms. Retrospective inquiry showed the animal had been inoculated using complete Freund's adjuvant during a malaria vaccine trial. Lesions observed were compatible with lipid embolism of the adjuvant in the lungs. |
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Keywords: | Aotus lemurinus Cebidae Freund's adjuvant pathology primate tuberculosis‐like |
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