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Polymorphism of the pentanucleotide repeat d(AAAAT) within intron 1 of the human tumor suppressor gene p53 (17p13.1) |
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| Authors: | Meinhard Hahn Rainer Fislage Alfred Pingoud |
| Affiliation: | (1) Institut für Biochemie, FB 15, Justus-Liebig-Universität, Heinrich-Buff-Ring 58, D-35392 Giessen, Germany;(2) Zentrum Biochemie, OE 4350, Medizinische Hochschule Hannover, D-30623 Hannover, Germany |
| Abstract: | DyeDeoxy terminator cycle sequencing of allele-specific polymerase chain reaction products has shown that there is a highly polymorphic d(AAAAT) pentanucleotide repeat within the first intron of the human p53 gene. This provides a genetic marker for tumor suppressor p53 gene alterations. |
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