EFFECTS OF DI-ISOPROPYLFLUOROPHOSPHATE ON THE METABOLISM OF CHOLINE AND PHOSPHATIDYLCHOLINE IN RAT BRAIN |
| |
| Authors: | K. Dross |
| |
| Affiliation: | Institut für Klinische Pharmakologie der Freien Universität Berlin and C. und O. Vogt, Institut für Hirnforschung der Universität, Düsseldorf, Germany |
| |
| Abstract: | —The subcutaneous administration of 2·0 mg DFP per kg to rats causes a diminution in the lysophosphatidylcholine content in the brain, which is followed by a decrease of glycerylphosphorylcholine concentration and by a reduced post mortem choline increase. This supports the hypothesis that a post mortem increase in choline is due to phosphatidylcholine breakdown. Since the amount of phosphatidylcholine in brains of di-isopropylfluorophosphate-treated rats increases, it is concluded that phospholipase A is inhibited by di-isopropylfluorophosphate, which corresponds to findings of other authors in vitro. The activity of glycerylphosphorylcholine diesterase (EC 3.1.4.2) is not altered. |
| |
| Keywords: | |
|
|
