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Structurally designed novel furogamma lactams as inhibitors for bacterial propagations |
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| Authors: | Jayanta K Ray Izhar Sami Gandhi K Kar Bidhan C Roy Nitosh K Brahma |
| Institution: | a Department of Chemistry, Indian Institute of Technology, Kharagpur 721302, India b Department of Chemical Engineering, Indian Institute of Technology, Kharagpur 721302, India |
| Abstract: | Some novel furogamma lactams have been synthesised by one step condensation of arylaminomalonates with substituted furyl acryloyl chlorides. The annulation of substituted monocyclic gammalactams followed by cyclization produced novel tricyclic furogamma lactams. Some of these furogammalactams are found to exhibit Gram-positive and Gram-negative antibacterial activity at very high concentrations. |
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