Design, synthesis, and evaluation of octahydropyranopyrrole-based inhibitors of mammalian ribonucleotide reductase |
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| Authors: | Fuertes Michael J Kaur Jaskiran Deb Prasant Cooperman Barry S Smith Amos B |
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| Affiliation: | Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA. |
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| Abstract: | Inhibitors of mammalian ribonucleotide reductase possessing a novel octahydropyranopyrrole scaffold based on a cyclic heptapeptide inhibitor have been designed, synthesized, and evaluated. Structure-function studies reveal that the bicyclic scaffold is indeed necessary to maintain inhibitory activity. |
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