Green tea: a new option for the prevention or control of osteoarthritis |
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| Authors: | Santosh K Katiyar Chander Raman |
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| Institution: | (1) Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA;(2) Birmingham VA Medical Center, Birmingham, AL 35294, USA;(3) Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA |
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| Abstract: | IL-1β is a major cytokine driving the inflammatory processes leading to the pathophysiology of osteoarthritis and other inflammatory
diseases. Blockade of IL-1β activity using substances such as the naturally occurring IL-1 receptor antagonist or anti-IL-1β
monoclonal antibody are currently being used or tested as therapy. However, such treatments are ineffective in osteoarthritis.
In a recent study, epigallocatechin-3-gallate, a green tea polyphenol, was found to be effective in reducing IL-1β-induced
inflammatory cytokines, TNFα, IL-6, granulocyte-macrophage colony-stimulating factor and several chemokines from human chondrocytes.
The use of green tea polyphenols may be beneficial as a therapeutic addition to biologics that control IL-1β activity by increasing
effectiveness and/or reducing dosage. |
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