Intraarticular injection of hyaluronan prevents cartilage erosion,periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis |
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| Authors: | Anna Plaas Jun Li Julie Riesco Rosalina Das John D Sandy Andrew Harrison |
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| Institution: | (1) Department of Internal Medicine (Rheumatology), Rush University Medical Center, 1735 West Harrison Street, Chicago, IL 60612, USA;(2) Department of Biochemistry, Rush University Medical Center, Chicago, IL, USA;(3) Smith & Nephew Research Centre, York Science Park, Heslington, York, YO10 5DF, UK |
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| Abstract: | Introduction Intraarticular hyaluronan (HA) is used clinically for symptomatic relief in patients with knee osteoarthritis (OA); however,
the mechanism of action is unclear. In this study, we examined the effects of a single injection of HA on joint tissue pathology,
mechanical allodynia and gait changes (measured by stride times) in a murine model of OA. |
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