Stem Cell Glycolipids |
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Authors: | Makoto Yanagisawa |
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Institution: | (1) Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street-CA4040, Augusta, GA 30912, USA |
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Abstract: | Glycolipids are compounds containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety.
Because of their expression patterns and the intracellular localization patterns, glycolipids, including stage-specific embryonic
antigens (SSEA-3, SSEA-4, and possibly SSEA-1) and gangliosides (e.g., GD3, GD2, and A2B5 antigens), have been used as marker
molecules of stem cells. In this review, I will introduce glycolipids expressed in pluripotent stem cells (embryonic stem
cells, induced pluripotent stem cells, very small embryonic-like stem cells, amniotic stem cells, and multilineage-differentiating
stress enduring cells), multipotent stem cells (neural stem cells, mesenchymal stem cells, fetal liver multipotent progenitor
cells, and hematopoietic stem cells), and cancer stem cells (brain cancer stem cells and breast cancer stem cells), and discuss
their availability as biomarkers for identifying and isolating stem cells. |
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Keywords: | |
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