Y-700, a novel inhibitor of xanthine oxidase, suppresses the development of colon aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine-treated mice |
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Authors: | Hashimoto Takao Fukunari Atsushi Yamada Ichimaro Yanaka Noriyuki Chen Dong Kato Norihisa |
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Institution: | Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima, Japan. |
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Abstract: | Y-700, 1-3-cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid, is a newly synthesized inhibitor of xanthine oxidase. This study found that feeding of Y-700 suppressed the development of colonic aberrant crypt foci, precursor lesions of colon cancer, and cell proliferation in 1,2-dimethylhydrazine-treated mice, accompanied by reduced serum urate. These results suggest that Y-700 is a useful agent for the prevention of colon tumorigenesis and that xanthine oxidase plays an important role in the development of colon cancer. |
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