Effects of chronic antidepressant treatment on dopamine-related [3H]SCH 23390 and [3H]Spiperone binding in the rat striatum |
| |
Authors: | Paul R. Paetsch Andrew J. Greenshaw |
| |
Affiliation: | Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Canada. |
| |
Abstract: | 1. The effects of chronic administration of antidepressants on dopamine-related [3H]SCH 23390 and [3H]spiperone binding to rat striatal membranes were assessed. 2. The monoamine oxidase inhibitors phenelzine (5 or 10 mg kg-1/day) and tranylcypromine (1 mg kg-1/day) and the tricyclic desipramine (10 mg kg-1/day) were administered for 28 days by constant subcutaneous infusion using Alzet (2ML4) osmotic minipumps. 3. These treatments did not alter Kd estimates for either [3H]SCH 23390 or [3H]spiperone binding sites. The monoamine oxidase inhibitors induced a decrease in the Bmax values for both [3H]SCH 23990 and [3H]spiperone binding sites. Desipramine induced a decrease in the Bmax value for [3H]SCH 23390 binding but had no effect on the Bmax value for [3H]spiperone binding. |
| |
Keywords: | dopamine receptor subtypes [3H]SCH 23390 [3H]spiperone monoamine oxidase inhibitors desipramine striatum |
本文献已被 SpringerLink 等数据库收录! |