Proliferating cells in histiocytic necrotizing lymphadenitis |
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Authors: | Kohichi Ohshima Masahiro Kikuchi Yoshiaki Sumiyoshi Yuhichi Masuda Hidehito Mohtai Fuyuki Eguchi Morishige Takeshita |
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Institution: | 1. First Department of Pathology, School of Medicine, Fukuoka University, Nanakuma 7-45-1, Jyonan-ku, 814-01, Fukuoka, Japan
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Abstract: | The phenotypes of proliferating cells in histiocytic necrotizing lymphadenitis (HNL) were examined. The affected areas consisted
mainly of CD 8-positive (suppressor/cytotoxic T-cells) and CD 4-positive (helper/inducer T-cells) in association with some
CD 15-positive cells (monocytes). A marker of proliferating cells (Ki-67) and monoclonal antibodies for determining the phenotypes
of cells (CD 4, CD 8, CD 15) in the affected areas were applied using a double-staining method. Ki-67-positive proliferating
cells were mainly CD 8-positive. A few CD 4-positive cells and rare CD 15-positive cells were also Ki-67-positive. The percentage
of CD 8-positive cells increased gradually over time and the ratio of CD 8-positive to proliferating cells did not decrease
throughout the observation period of 6 weeks. These results suggest that the proliferation of CD 8-positive T-cells together
with the accumulation of CD 4- and CD 15-positive cells is the main phenomenon occurring in HNL. |
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Keywords: | Histiocytic necrotizing lymphadenitis Proliferating cells CD 4 CD 8 CD 15 |
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