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Immunoprophylaxis of respiratory syncytial virus: global experience
Authors:Eric AF Simoes
Affiliation:(1) Division of Molecular Immunology, Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany;(2) Division of Clinical Immunopathophysiology, Department of Clinical Medicine, Research Center Borstel, Borstel, Germany
Abstract:In sarcoidosis, host genetic factors are discussed as contributing to disease susceptibility and course. Since tumor necrosis factor (TNF)-α is a central mediator of granuloma formation and since elevated TNF-α levels are found during active phases of sarcoidosis, genetic polymorphisms correlating with influences on TNF-α levels are of special interest. The complete sequencing of the MHC region and the increase in the number of identified gene polymorphisms in this locus associated with TNF-α production offer the opportunity of detecting new genes associated with sarcoidosis and perhaps of defining disease-associated haplotypes that bear the potential of serving as predictive markers for this disease.
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